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A Brief Review of Artificial Intelligence Applications and Algorithms for Psychiatric Disorders Review
Guang-Di Liu, Yu-Chen Li, Wei Zhang, Le Zhang
Engineering 2020, Volume 6, Issue 4, Pages 462-467 doi: 10.1016/j.eng.2019.06.008
Keywords: Artificial intelligence Psychiatric disorders Neuroimaging
Dongping Ning, Zhan Zhang, Kun Qiu, Lin Lu, Qin Zhang, Yan Zhu, Renzhi Wang
Frontiers of Medicine 2020, Volume 14, Issue 4, Pages 498-505 doi: 10.1007/s11684-020-0791-8
Keywords: disorders of sex development (DSD) intelligent diagnosis dynamic uncertain causality graph
Therapeutic effects of thalidomide in hematologic disorders: a review
Miao Xu, Yu Hou, Lei Sheng, Jun Peng
Frontiers of Medicine 2013, Volume 7, Issue 3, Pages 290-300 doi: 10.1007/s11684-013-0277-z
Keywords: thalidomide multiple myeloma lymphoma
Mesenchymal stem cells and immune disorders: from basic science to clinical transition
Shihua Wang, Rongjia Zhu, Hongling Li, Jing Li, Qin Han, Robert Chunhua Zhao
Frontiers of Medicine 2019, Volume 13, Issue 2, Pages 138-151 doi: 10.1007/s11684-018-0627-y
Keywords: mesenchymal stem cell clinical transition immune disorders
Frontiers of Medicine doi: 10.1007/s11684-023-1006-x
Keywords: neurodevelopmental disorder autosomal recessive intellectual disability consanguinity spastic paraplegia hearing loss TMEM141
Yuqiu Han, Xiangyang Jiang, Qi Ling, Li Wu, Pin Wu, Ruiqi Tang, Xiaowei Xu, Meifang Yang, Lijiang Zhang, Weiwei Zhu, Baohong Wang, Lanjuan Li
Frontiers of Medicine 2019, Volume 13, Issue 4, Pages 471-481 doi: 10.1007/s11684-019-0686-8
Keywords: antibiotics tacrolimus glucose disorders microbiome
XU Leping, JI Juying, DUAN Yiyang, SHI Hui, ZHANG Bin, SHAO Yaqin, SUN Jian
Frontiers of Medicine 2007, Volume 1, Issue 3, Pages 316-319 doi: 10.1007/s11684-007-0061-z
Keywords: significant difference occurrence hemoglobin risperidone treatment abnormal
Tingting Peng, Yangyan Chen, Wanshan Hu, Yao Huang, Minmin Zhang, Chao Lu, Xin Pan, Chuanbin Wu
Engineering 2023, Volume 30, Issue 11, Pages 170-189 doi: 10.1016/j.eng.2023.05.009
Microneedles (MNs) can be used for the topical treatment of skin disorders as they directly delivermolecules, macromolecules, nanomedicines, living cells, bacteria, and exosomes) for treating various skin disorderssummarized the various applications, emerging challenges, and developmental prospects of MNs in skin disorders
Keywords: Microneedles Transdermal drug delivery system Skin disorders Treatments Challenges Prospects
Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders Review
Wanqiang Wu, Qingmin Kong, Peijun Tian, Qixiao Zhai, Gang Wang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Yuan Kun Lee, Wei Chen
Engineering 2020, Volume 6, Issue 4, Pages 415-423 doi: 10.1016/j.eng.2019.07.026
Keywords: Gut microbiota Gut–brain axis Neurological disorders Intervention strategies
Physiological functions and clinical implications of the N-end rule pathway
Yujiao Liu,Chao Liu,Wen Dong,Wei Li
Frontiers of Medicine 2016, Volume 10, Issue 3, Pages 258-270 doi: 10.1007/s11684-016-0458-7
The N-end rule pathway is a unique branch of the ubiquitin-proteasome system in which the determination of a protein’s half-life is dependent on its N-terminal residue. The N-terminal residue serves as the degradation signal of a protein and thus called N-degron. N-degron can be recognized and modifed by several steps of post-translational modifications, such as oxidation, deamination, arginylation or acetylation, it then polyubiquitinated by the N-recognin for degradation. The molecular basis of the N-end rule pathway has been elucidated and its physiological functions have been revealed in the past 30 years. This pathway is involved in several biological aspects, including transcription, differentiation, chromosomal segregation, genome stability, apoptosis, mitochondrial quality control, cardiovascular development, neurogenesis, carcinogenesis, and spermatogenesis. Disturbance of this pathway often causes the failure of these processes, resulting in some human diseases. This review summarized the physiological functions of the N-end rule pathway, introduced the related biological processes and diseases, with an emphasis on the inner link between this pathway and certain symptoms.
Keywords: N-end rule pathway Ate1 cardiovascular development neurogenesis spermatogenesis neurodegenerative disorders
Ying Zhang, Jiaming Ju, Lei Jiao, Baofeng Yang
Engineering 2023, Volume 29, Issue 10, Pages 73-82 doi: 10.1016/j.eng.2023.03.004
Disturbed cholesterol and glucose homeostasis play crucial roles in the development of various diseases such as cardiovascular diseases, cerebrovascular diseases, central nervous system diseases, and cancer. An increasing number of studies have shown that excessive body fat accumulation is associated with type 2 diabetes or insulin resistance in a vicious cycle. This vicious cycle promotes the occurrence and development of the aforementioned diseases. Therefore, stabilizing the blood lipids and blood glucose of patients is the predominant strategy for improving the symptoms of patients with cardiovascular, cerebrovascular, and central nervous system diseases. Traditional Chinese medicine, mainly Chinese herbal medicine (CHM), has a history of more than 2000 years in China, which has established a unique theory and accumulated a great wealth of clinical experience. Moreover, CHM has been widely used in China and other countries for the treatment of cardiovascular and cerebrovascular diseases, with the advantages of preventing and curing hyperlipidemia, diabetes, hypertension, and other diseases. However, the use of CHM in Western countries remains rather limited, partly because of the incomplete understanding of multiple complex components and uncertain pharmacological mechanisms. Herein, we review and discuss the benefits, molecular mechanisms, and clinical research progress of bioactive components of CHM and their preparations as therapeutics for hyperlipidemia and hyperglycemia.
Keywords: Chinese herbal medicines Hyperlipidemia Hyperglycemia Cardiovascular and cerebrovascular diseases
Metabonomic study of the biochemical profiles of heterozygous myostatin knockout swine
Jianxiang XU,Dengke PAN,Jie ZHAO,Jianwu WANG,Xiaohong HE,Yuehui MA,Ning LI
Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1, Pages 90-99 doi: 10.15302/J-FASE-2015045
Keywords: myostatin transforming growth factor-β family skeletal muscle metabolic disorders chromatography mass
Recent advances in myeloid-derived suppressor cell biology
Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud
Frontiers of Medicine 2021, Volume 15, Issue 2, Pages 232-251 doi: 10.1007/s11684-020-0797-2
Keywords: non-human primates (rhesus macaques) myeloid-derived pro-inflammatory cells (MDPCs) autoimmune disorders
Title Author Date Type Operation
A Brief Review of Artificial Intelligence Applications and Algorithms for Psychiatric Disorders
Guang-Di Liu, Yu-Chen Li, Wei Zhang, Le Zhang
Journal Article
Efficacy of intelligent diagnosis with a dynamic uncertain causality graph model for rare disorders of
Dongping Ning, Zhan Zhang, Kun Qiu, Lin Lu, Qin Zhang, Yan Zhu, Renzhi Wang
Journal Article
Therapeutic effects of thalidomide in hematologic disorders: a review
Miao Xu, Yu Hou, Lei Sheng, Jun Peng
Journal Article
Mesenchymal stem cells and immune disorders: from basic science to clinical transition
Shihua Wang, Rongjia Zhu, Hongling Li, Jing Li, Qin Han, Robert Chunhua Zhao
Journal Article
Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function
Journal Article
Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders
Yuqiu Han, Xiangyang Jiang, Qi Ling, Li Wu, Pin Wu, Ruiqi Tang, Xiaowei Xu, Meifang Yang, Lijiang Zhang, Weiwei Zhu, Baohong Wang, Lanjuan Li
Journal Article
Abnormal glycosylated hemoglobin as a predictive factor for glucose metabolism disorders in antipsychotic
XU Leping, JI Juying, DUAN Yiyang, SHI Hui, ZHANG Bin, SHAO Yaqin, SUN Jian
Journal Article
Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and Prospects
Tingting Peng, Yangyan Chen, Wanshan Hu, Yao Huang, Minmin Zhang, Chao Lu, Xin Pan, Chuanbin Wu
Journal Article
Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders
Wanqiang Wu, Qingmin Kong, Peijun Tian, Qixiao Zhai, Gang Wang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Yuan Kun Lee, Wei Chen
Journal Article
Physiological functions and clinical implications of the N-end rule pathway
Yujiao Liu,Chao Liu,Wen Dong,Wei Li
Journal Article
Bioactive Components of Chinese Herbal Medicines in the Treatment of Glucose and Lipid Metabolism Disorders
Ying Zhang, Jiaming Ju, Lei Jiao, Baofeng Yang
Journal Article
Metabonomic study of the biochemical profiles of heterozygous myostatin knockout swine
Jianxiang XU,Dengke PAN,Jie ZHAO,Jianwu WANG,Xiaohong HE,Yuehui MA,Ning LI
Journal Article